Long-term follow-up of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linking to halt the progression of keratoconus.

نویسندگان

  • David P S O'Brart
  • Tsong Q Kwong
  • Parul Patel
  • Robert J McDonald
  • Naomi A O'Brart
چکیده

AIMS To determine long-term efficacy of riboflavin/ultraviolet A corneal cross-linking (CXL). METHODS Thirty patients (30 eyes) who had undergone CXL following epithelial removal 4-6 years previously were examined. RESULTS At 1-year mean, spherical equivalent error (SEQ) increased by +0.72 dioptres (D) (p<0.002), corrected distance visual acuity (CDVA) improved (p<0.005), mean simulated keratometry (Sim K) reduced by 0.27D (p<0.04), cone apex power (CAP) reduced by 0.4D (p<0.02), and secondary astigmatism improved (p<0.03) compared with preoperative values. At 4-6 years, mean SEQ increased by +0.82D (p<0.001), CDVA improved (p<0.03), mean Sim K reduced by 0.84D (p<0.00001), CAP reduced by 1.16D (p<0.0005), and root mean square (RMS) (p<0.0001), coma (p<0.0001), secondary astigmatism (p<0.005) and pentafoil (p<0.05) decreased compared with preoperative values. At 4-6 years, mean Sim K reduced by 0.59D (p<0.0005), CAP reduced by 0.76D (p<0.02), RMS (p<0.001), coma (p<0.002) and secondary astigmatism (p<0.02) reduced and central pachymetry increased (p<0.05) compared with 1 year. No treated eyes progressed. None lost >1 line of CDVA. Seven untreated fellow eyes progressed. CONCLUSIONS CXL is an effective and safe treatment with up to 4-6 years follow-up. Improvements in topographic and wave-front parameters evident at 1 year continue to improve at 4-6 years.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

MONTHLY RESEARCH UPDATE Long-term follow-up of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linking to halt the progression of keratoconus

With our background in clinical ophthalmic research, mainly of the anterior eye, Bausch and Lomb have asked us to produce an independent report of some of the interesting findings coming out of the research journals each month. As a busy practitioner, this should allow you to keep more up-to-date with cutting edge clinical research and allow you to locate the articles when you want to know more...

متن کامل

A randomised, prospective study to investigate the efficacy of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linkage to halt the progression of keratoconus.

AIMS A blind, randomised, prospective, bilateral study to investigate the efficacy of riboflavin/ultraviolet A corneal collagen cross-linkage to halt the progression of keratoconus. METHODS 24 patients with early/moderate bilateral keratoconus with recent progression were recruited. One eye was randomly assigned to undergo collagen cross-linkage following epithelial removal with riboflavin 0....

متن کامل

Corneal collagen cross-linking (CXL) in thin corneas

Corneal collagen cross-linking (CXL) is a therapeutic procedure aiming at increasing the corneal stiffness in the keratoconus eyes by induction of cross-links within the extracellular matrix. It is achieved by ultraviolet-A (370 nm) irradiation of the cornea after saturation with the photosensitizer riboflavin. In the conventional CXL protocol, a minimum de-epithelialized corneal thickness of 4...

متن کامل

Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus.

PURPOSE In animal eyes, a significant increase in corneal biomechanical stiffness has been found after collagen crosslinking by combined riboflavin/ultraviolet-A (UVA) treatment. The aim of the present study was to evaluate the clinical usefulness of riboflavin/UVA-induced collagen crosslinking for bringing the progression of keratoconus to a halt. DESIGN Prospective, nonrandomized clinical p...

متن کامل

Corneal collagen cross-linking: a review.

The aim was to review the published literature on corneal collagen cross-linking. The emphasis was on the seminal publications, systemic reviews, meta-analyses and randomized controlled trials. Where such an evidence did not exist, selective large series cohort studies, case controlled studies and case series with follow-up preferably greater than 12 months were included. Riboflavin/Ultraviolet...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The British journal of ophthalmology

دوره 97 4  شماره 

صفحات  -

تاریخ انتشار 2013